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Applications

Nanoscale homogeneity

  • Molecular assemblies

  • Photoresists, Fate of Photoacid Generator, PAG

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Proc. SPIE 12055, doi: 10.1117/12.2612602

Characterization of Individual Nano-objects

  • Extracellular vesicles

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EVs captured on Au surface, labeld with Abs carrying Ln-tags, and analyzed NP-SIMS

ACS Nano 2023, 17, 23584

Selected region of mass spectra comparing tagged and untagged EVs.

ACS Nano 2023, 17, 23584

  • Loading on Nano Stars

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Branched particles exhibit increased ligand loading versus Nano spheres. Anal. Chem. 2019, 91, 5566

  • Intermixing of Nanoparticles (3-5nm diameter) and interweaving of ligands

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Molecular analysis of nano-objects and their interfaces can be carried out at the scale below 5nm. Anal Chem, 2022, 94, 7868-7876

  • Nanoparticle organization at the Nano scale

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NP-SIMS enables to determine 

a) the extent of comingled molecules i.e. homogeneity at the nanoscale and b) the respective surface coverages of mixed and segregated components. Anal Chem, 2016, 88, 7639-7646.

Nanoscale Topography

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