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Applications
Nanoscale homogeneity
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Molecular assemblies
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Photoresists, Fate of Photoacid Generator, PAG

Proc. SPIE 12055, doi: 10.1117/12.2612602
Characterization of Individual Nano-objects
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Extracellular vesicles


EVs captured on Au surface, labeld with Abs carrying Ln-tags, and analyzed NP-SIMS
ACS Nano 2023, 17, 23584
Selected region of mass spectra comparing tagged and untagged EVs.
ACS Nano 2023, 17, 23584
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Loading on Nano Stars



Branched particles exhibit increased ligand loading versus Nano spheres. Anal. Chem. 2019, 91, 5566
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Intermixing of Nanoparticles (3-5nm diameter) and interweaving of ligands

Molecular analysis of nano-objects and their interfaces can be carried out at the scale below 5nm. Anal Chem, 2022, 94, 7868-7876
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Nanoparticle organization at the Nano scale

NP-SIMS enables to determine
a) the extent of comingled molecules i.e. homogeneity at the nanoscale and b) the respective surface coverages of mixed and segregated components. Anal Chem, 2016, 88, 7639-7646.
Nanoscale Topography


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